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The principal cytochrome P450 isoenzyme involved appears to generally be CYP2E1, with CYP1A2 and CYP3A4 as supplemental pathways. Close to 85% of an oral dose appears within the urine inside 24 several hours of administration, most as the glucuronide conjugate, with tiny quantities of other conjugates and unchanged drug (see OVERDOSAGE) for toxicit